Top 100 Most-Cited Papers

The 100 most-cited papers across the perianal & luminal Crohn's-disease literature, by citation count (NIH Open Citation Collection).

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

  1. Present DH · 1999 · The New England journal of medicine · Infliximab for the treatment of fistulas in patients with Crohn's disease.2,132 cites
  2. Lamb CA · 2019 · Gut · British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.1,824 cites
  3. Sands BE · 2004 · The New England journal of medicine · Infliximab maintenance therapy for fistulizing Crohn's disease.1,713 cites
  4. Gomollón F · 2017 · Journal of Crohn's & colitis · 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management.1,556 cites
  5. Baumgart DC · 2007 · Lancet (London, England) · Inflammatory bowel disease: clinical aspects and established and evolving therapies.1,440 cites
  6. Caplan AI · 2007 · Journal of cellular physiology · Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.1,380 cites
  7. Torres J · 2020 · Journal of Crohn's & colitis · ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.1,089 cites
  8. Greenstein AJ · 1976 · Medicine · The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.1,062 cites
  9. Fazio VW · 1995 · Annals of surgery · Ileal pouch-anal anastomoses complications and function in 1005 patients.958 cites
  10. Shi Y · 2018 · Nature reviews. Nephrology · Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.923 cites
  11. Panés J · 2016 · Lancet (London, England) · Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.815 cites
  12. Ruemmele FM · 2014 · Journal of Crohn's & colitis · Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.811 cites
  13. Schwartz DA · 2002 · Gastroenterology · The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota.801 cites
  14. Sartor RB · 2004 · Gastroenterology · Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics.756 cites
  15. Beaugerie L · 2006 · Gastroenterology · Predictors of Crohn's disease.712 cites
  16. D'Haens GR · 1998 · Gastroenterology · Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum.682 cites
  17. Singer NG · 2011 · Annual review of pathology · Mesenchymal stem cells: mechanisms of inflammation.661 cites
  18. Ng SC · 2013 · Gastroenterology · Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study.646 cites
  19. Thia KT · 2010 · Gastroenterology · Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort.634 cites
  20. Rutgeerts P · 1991 · Lancet (London, England) · Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum.598 cites
  21. García-Olmo D · 2005 · Diseases of the colon and rectum · A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation.587 cites
  22. Gionchetti P · 2017 · Journal of Crohn's & colitis · 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 2: Surgical Management and Special Situations.576 cites
  23. Garcia-Olmo D · 2009 · Diseases of the colon and rectum · Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial.573 cites
  24. van Rheenen PF · 2021 · Journal of Crohn's & colitis · The Medical Management of Paediatric Crohn's Disease: an ECCO-ESPGHAN Guideline Update.544 cites
  25. Worthey EA · 2011 · Genetics in medicine : official journal of the American College of Medical Genetics · Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease.516 cites
  26. Bernell O · 2000 · Annals of surgery · Risk factors for surgery and postoperative recurrence in Crohn's disease.515 cites
  27. González MA · 2009 · Gastroenterology · Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses.502 cites
  28. Fallingborg J · 1999 · Danish medical bulletin · Intraluminal pH of the human gastrointestinal tract.500 cites
  29. De Miguel MP · 2012 · Current molecular medicine · Immunosuppressive properties of mesenchymal stem cells: advances and applications.497 cites
  30. Peyrin-Biroulet L · 2008 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials.482 cites
  31. Lichtenstein GR · 2005 · Gastroenterology · Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease.469 cites
  32. Rankin GB · 1979 · Gastroenterology · National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications.443 cites
  33. Sandborn WJ · 2003 · Gastroenterology · AGA technical review on perianal Crohn's disease.441 cites
  34. Ciccocioppo R · 2011 · Gut · Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease.440 cites
  35. Naji A · 2019 · Cellular and molecular life sciences : CMLS · Biological functions of mesenchymal stem cells and clinical implications.439 cites
  36. Farmer RG · 1985 · Gastroenterology · Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis.428 cites
  37. Adamina M · 2020 · Journal of Crohn's & colitis · ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.427 cites
  38. Khan KJ · 2011 · The American journal of gastroenterology · Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis.398 cites
  39. Matsuoka K · 2018 · Journal of gastroenterology · Evidence-based clinical practice guidelines for inflammatory bowel disease.396 cites
  40. Brandt LJ · 1982 · Gastroenterology · Metronidazole therapy for perineal Crohn's disease: a follow-up study.395 cites
  41. Clifford GM · 2021 · International journal of cancer · A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.392 cites
  42. Gajendran M · 2018 · Disease-a-month : DM · A comprehensive review and update on Crohn's disease.379 cites
  43. Sandborn WJ · 1999 · Inflammatory bowel diseases · Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety.369 cites
  44. Feuerstein JD · 2017 · Mayo Clinic proceedings · Crohn Disease: Epidemiology, Diagnosis, and Management.368 cites
  45. Hellers G · 1980 · Gut · Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.364 cites
  46. Nguyen GC · 2016 · Gastroenterology · The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy.358 cites
  47. D'Haens GR · 2011 · The American journal of gastroenterology · The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?354 cites
  48. Panés J · 2018 · Gastroenterology · Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease.353 cites
  49. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition · 2007 · Journal of pediatric gastroenterology and nutrition · Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America.351 cites
  50. Schwartz DA · 2001 · Gastroenterology · A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas.351 cites
  51. Mekhjian HS · 1979 · Gastroenterology · Clinical features and natural history of Crohn's disease.345 cites
  52. Peyrin-Biroulet L · 2016 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.345 cites
  53. Feuerstein JD · 2021 · Gastroenterology · AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease.329 cites
  54. Rutgeerts P · 2004 · Gastroenterology · Optimizing anti-TNF treatment in inflammatory bowel disease.327 cites
  55. Bernstein LH · 1980 · Gastroenterology · Healing of perineal Crohn's disease with metronidazole.326 cites
  56. Sandborn WJ · 1994 · Gastroenterology · Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis, and treatment.319 cites
  57. Rogler G · 2014 · Cancer letters · Chronic ulcerative colitis and colorectal cancer.318 cites
  58. Jess T · 2007 · Inflammatory bowel diseases · Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark.314 cites
  59. Nguyen GC · 2008 · The American journal of gastroenterology · Rising prevalence of venous thromboembolism and its impact on mortality among hospitalized inflammatory bowel disease patients.310 cites
  60. Gecse KB · 2014 · Gut · A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease.305 cites
  61. Malouf AJ · 2000 · Lancet (London, England) · Long-term results of overlapping anterior anal-sphincter repair for obstetric trauma.303 cites
  62. Van Assche G · 2003 · The American journal of gastroenterology · Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease.300 cites
  63. Hahnloser D · 2007 · The British journal of surgery · Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis.297 cites
  64. Yanai H · 2011 · The American journal of gastroenterology · Assessing response and loss of response to biological therapies in IBD.282 cites
  65. Buisson A · 2012 · Alimentary pharmacology & therapeutics · Review article: the natural history of postoperative Crohn's disease recurrence.282 cites
  66. Revuz J · 2009 · Journal of the European Academy of Dermatology and Venereology : JEADV · Hidradenitis suppurativa.274 cites
  67. Bernell O · 2000 · The British journal of surgery · Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease.273 cites
  68. Ponsioen CY · 2017 · The lancet. Gastroenterology & hepatology · Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.270 cites
  69. Dulai PS · 2016 · The American journal of gastroenterology · The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn's Disease: Results From the US VICTORY Consortium.268 cites
  70. Irvine EJ · 1995 · Journal of clinical gastroenterology · Usual therapy improves perianal Crohn's disease as measured by a new disease activity index. McMaster IBD Study Group.267 cites
  71. de la Portilla F · 2013 · International journal of colorectal disease · Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial.267 cites
  72. Ehrenpreis ED · 1999 · Gastroenterology · Thalidomide therapy for patients with refractory Crohn's disease: an open-label trial.266 cites
  73. Molendijk I · 2015 · Gastroenterology · Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.259 cites
  74. Yarur AJ · 2017 · Alimentary pharmacology & therapeutics · Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease.252 cites
  75. Kirsner JB · 1982 · The New England journal of medicine · Recent developments in "nonspecific" inflammatory bowel disease (first of two parts).251 cites
  76. Sands BE · 2004 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study.248 cites
  77. Farrokhyar F · 2006 · Inflammatory bowel diseases · Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: prevalence and impact on health.247 cites
  78. Tulchinsky H · 2003 · Annals of surgery · Long-term failure after restorative proctocolectomy for ulcerative colitis.243 cites
  79. Sainio P · 1984 · Annales chirurgiae et gynaecologiae · Fistula-in-ano in a defined population. Incidence and epidemiological aspects.242 cites
  80. Loly C · 2008 · Scandinavian journal of gastroenterology · Predictors of severe Crohn's disease.241 cites
  81. Torres J · 2012 · Inflammatory bowel diseases · Ulcerative colitis as a progressive disease: the forgotten evidence.240 cites
  82. Ricart E · 2001 · The American journal of gastroenterology · Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients.236 cites
  83. Sandborn WJ · 2003 · Gastroenterology · Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial.234 cites
  84. Korelitz BI · 1985 · Digestive diseases and sciences · Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease.232 cites
  85. García-Olmo D · 2003 · International journal of colorectal disease · Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy.230 cites
  86. Cleynen I · 2013 · Gut · Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.229 cites
  87. Cosnes J · 2013 · Gastroenterology · Early administration of azathioprine vs conventional management of Crohn's Disease: a randomized controlled trial.227 cites
  88. Riekstina U · 2009 · Stem cell reviews and reports · Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis.224 cites
  89. Nguyen GC · 2006 · The American journal of gastroenterology · Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort.224 cites
  90. Neut C · 2002 · The American journal of gastroenterology · Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease.220 cites
  91. Panés J · 2017 · Nature reviews. Gastroenterology & hepatology · Perianal fistulizing Crohn's disease: pathogenesis, diagnosis and therapy.218 cites
  92. Sonoda T · 2002 · Diseases of the colon and rectum · Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap.218 cites
  93. Mizrahi N · 2002 · Diseases of the colon and rectum · Endorectal advancement flap: are there predictors of failure?217 cites
  94. Malgieri A · 2010 · International journal of clinical and experimental medicine · Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art.216 cites
  95. Lee WY · 2013 · Stem cells (Dayton, Ohio) · Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula.216 cites
  96. Regueiro M · 2003 · Inflammatory bowel diseases · Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement.215 cites
  97. Atwell JD · 1965 · The British journal of surgery · The outcome of Crohn's disease.213 cites
  98. Ungaro RC · 2020 · Gastroenterology · Deep Remission at 1 Year Prevents Progression of Early Crohn's Disease.212 cites
  99. Whelan G · 1985 · Gastroenterology · Recurrence after surgery in Crohn's disease. Relationship to location of disease (clinical pattern) and surgical indication.210 cites
  100. Newman RE · 2009 · Inflammation & allergy drug targets · Treatment of inflammatory diseases with mesenchymal stem cells.208 cites