Wiki — Pcrohns
50 questions, drawn from this site's literature corpus. Draft pages are not yet clinician-reviewed.
What is the rate of anastomotic leakage within 30 days after LAR when an endorectal advancement flap is used draftIn patients with prior pelvic radiation undergoing LAR, does an endorectal advancement flap improve healing and reduce complications draftWhat are the limitations and conflicting evidence on endorectal advancement flaps for preventing postoperative fecal incontinence after LAR draftWhat is the typical recurrence rate after endoscopic balloon dilatation for anal stenosis in adults draftIn elderly patients with symptomatic anal stenosis and mild comorbidities, is endoscopic balloon dilation or surgical excision with primary repair preferred draftWhat is the evidence that high‑pressure balloon dilation reduces recurrence compared with low‑pressure dilation in anal stenosis draftWhat is the recommended induction dosing schedule for infliximab in patients with fistulising CD draftDoes adalimumab achieve higher rates of complete fistula closure at 24 weeks than certolizumab pegol in patients with perianal CD draftWhat is the evidence for anti‑TNF therapy as first‑line over surgical repair alone for reducing long‑term recurrence of perianal fistulas draftWhat is the standard intravenous dosing schedule of metronidazole for treatment of peritonitis due to perforated diverticulitis draftDoes adding ciprofloxacin to metronidazole improve 30‑day survival in patients with polymicrobial intra-abdominal sepsis compared with metronidazole alone draftIn intra-abdominal sepsis with estimated creatinine clearance 25 mL/min, is reduced-dose ciprofloxacin or a switch entirely to metronidazole preferred for anaerobic coverage draftWhy do randomized trials comparing ciprofloxacin monotherapy versus combination therapy with metronidazole in intra-abdominal sepsis report conflicting mortality outcomes, and what methodological issues may underlie these discrepancies draftWhat is the recommended interval between seton placement and initiation of infliximab in patients with complex perianal CD draftWhat is the definition of complete continence according to the Wexner scoring system draftWhat is the evidence for sacral nerve stimulation over biofeedback for improving fecal incontinence and quality of life after failed sphincter preservation draftDoes a loop ileostomy provide superior fecal diversion compared with a loop colostomy in reducing postoperative perianal wound complications draftIn patients with CD and an active high trans‑sphincteric perianal fistula who have failed initial seton drainage, is diverting ileostomy before definitive fistulotomy or proceeding directly to fistulotomy preferred draftWhat is the typical healing rate after placing a bioprosthetic fistula plug for low transsphincteric anal fistulas in adults draftWhat is the evidence that simple fistulotomy reduces recurrence rates compared with other sphincter-preserving techniques in patients with CD draftIn patients with an IBD-associated high transsphincteric fistula, is LIFT or advancement flap repair preferred to maximize healing while preserving sphincter function draftIn a young woman with a low intersphincteric fistula who wishes to avoid fecal incontinence, is LIFT or simple fistulotomy preferred draftWhere does the evidence conflict on long‑term recurrence and continence outcomes after LIFT in patients with CD draftWhat are the limitations of the evidence on long‑term safety and efficacy of darvadstrocel in perianal CD draftIn biologic-naïve UC patients, does vedolizumab achieve higher rates of clinical remission at 52 weeks than ustekinumab draftIn UC patients who have failed two biologics, is adding upadacitinib or switching to risankizumab preferred for clinical remission draftWhat is the scoring range of the Perianal Disease Activity Index (PDAI) and what constitutes a clinically significant improvement draftIn CD patients with a high‑output perianal abscess, is immediate drainage or delayed drainage after initiating corticosteroids preferred draftHow does the Parks classification compare with the AGA classification in predicting surgical outcomes for perianal CD fistulas draftIn patients with a high trans‑sphincteric fistula and no associated abscess, is seton placement or primary repair preferred draftWhat is the evidence that the AGA classification accurately predicts recurrence rates after surgical treatment of complex perianal fistulas draftDoes endoanal ultrasound detect secondary tracts more accurately than EUA alone in patients with complex perianal CD draftWhat is the evidence that endoanal ultrasound accurately predicts recurrence risk after fistula repair compared with postoperative clinical follow-up alone draftWhat is the Van Assche score used for in pelvic MRI assessment of CD draftWhat is the evidence that operative intervention within 24 hours improves mortality in patients with perianal sepsis compared with delayed drainage draftWhat is the estimated incidence of squamous cell carcinoma arising in chronic perianal fistulae draftDoes wide local excision with primary closure result in lower recurrence rates than abdominoperineal resection for squamous cell carcinoma of a long-standing perianal fistula draftIn patients with a longstanding anal fistula who develop an ulcerated lesion suspicious for malignancy, is endoscopic ultrasound-guided biopsy or immediate surgical excision preferred draftIn patients with chronic CD and a long-standing perianal fistula showing recent rapid growth, is anti-TNF therapy alone or adding local radiation before surgery preferred draftWhat is the evidence for chemoradiation as definitive treatment for adenocarcinoma arising within a chronic anal fistula draftIn patients with a persistent perineal sinus after LAR with permanent colostomy, is vertical rectus abdominis myocutaneous flap or gracilis muscle flap reconstruction preferred draftWhat is the evidence that negative pressure wound therapy reduces persistent perineal sinus formation after proctectomy draftIn patients with CD and a complex rectovaginal fistula involving the posterior vaginal wall, is seton placement with delayed flap closure or immediate mucosal advancement flap preferred draftWhat is the typical duration recommended for maintaining a loose seton before removal in perianal abscess management draftDoes a cutting seton reduce fistula recurrence compared to a loose seton in patients with complex anal fistulas draftIn patients with a high-output perianal abscess after abdominoperineal resection, is a cutting seton or a temporary diverting stoma preferred for drainage control draftWhat is the evidence that seton placement improves long-term outcomes in perianal CD compared with anti‑TNF therapy alone draftDoes video-assisted anal fistula treatment with laser closure achieve lower recurrence rates than LIFT for low transsphincteric fistulas draftDoes microorganism‑specific antimicrobial prophylaxis reduce the risk of SSI in CD patients undergoing definitive surgery for gastrointestinal fistulas draftIn patients undergoing loop ileostomy for IBD, does closure technique (open vs laparoscopic) affect the rate of subsequent pouch-related complications such as inflammation or stricture draft