Does adding ciprofloxacin to metronidazole improve 30‑day survival in patients with polymicrobial intra-abdominal sepsis compared with metronidazole alone

the retrieved corpus does not address 30-day survival in polymicrobial intra-abdominal sepsis for ciprofloxacin-plus-metronidazole versus metronidazole alone. the chunks that mention these two antibiotics concern pouchitis and perianal crohn's fistula/abscess management, and report symptomatic/disease-activity endpoints, not sepsis mortality ^1–4.

## References

1. Barreiro-de Acosta M, Gutierrez A, Rodríguez-Lago I, Espín E, Ferrer Bradley I, Marín-Jimenez I, Beltrán B, Chaparro M, Gisbert JP, Nos P, en representación de GETECCU. Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 1: Epidemiology, diagnosis and prognosis. Gastroenterol Hepatol. 2019;42(9):568-578. PMID: 31606162.

2. Gabbiadini R, Dal Buono A, Correale C, Spinelli A, Repici A, Armuzzi A, Roda G. Ileal Pouch-Anal Anastomosis and Pouchitis: The Role of the Microbiota in the Pathogenesis and Therapy. Nutrients. 2022;14(13):ePub only. PMID: 35807791.

3. Singh B, McC Mortensen NJ, Jewell DP, George B. Perianal Crohn's disease. Br J Surg. 2004;91(7):801-14. PMID: 15227686.

4. Mendoza JL, Taxonera C, Lana R, Alba C, García-Paredes J, Díaz-Rubio M. Diagnostic and treatment recommendations on perianal Crohn's disease. Rev Esp Enferm Dig. 2005;97(1):46-56. PMID: 15801897.

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_Draft — generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._