Why do randomized trials comparing ciprofloxacin monotherapy versus combination therapy with metronidazole in intra-abdominal sepsis report conflicting mortality outcomes, and what methodological issues may underlie these discrepancies

no retrieved source addresses ciprofloxacin monotherapy versus ciprofloxacin-plus-metronidazole in intra-abdominal sepsis, and none reports mortality outcomes — the indexed chunks concern ciprofloxacin/metronidazole for luminal Crohn's, perianal fistulas, and pouchitis, not surgical intra-abdominal sepsis. this question falls outside the Crohn's-surgery corpus and cannot be answered from the evidence retrieved.

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_Draft — generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._