Does wide local excision with primary closure result in lower recurrence rates than abdominoperineal resection for squamous cell carcinoma of a long-standing perianal fistula

What is known

- Abdominoperineal resection is described as the gold-standard treatment for fistula-associated anal carcinoma in Crohn's disease ¹. - One report notes neoadjuvant chemoradiation followed by APR produced complete responses in a small series ¹.

What is unknown / caveats

- The retrieved evidence does not support a comparison — no retrieved source reports outcomes for wide local excision with primary closure or compares recurrence rates between the two approaches.

## References

1. Papaconstantinou I, Mantzos DS, Kondi-Pafiti A, Koutroubakis IE. Anal adenocarcinoma complicating chronic Crohn's disease. Int J Surg Case Rep. 2015;10:201-3. PMID: 25884608.

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_Draft — generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._